Cytotoxic Drug Safety Cabinets (CDSC) Testing

WHY TEST CYTOTOXIC DRUG SAFETY CABINETS?

• To ensure the protection of personnel engaged in mechanical maintenance from exposure to the build-up of drug particles which contaminate filters and mechanical components.
• To ensure the protection of the surrounding environment and of those personnel not involved in the preparation and use of these drugs.
• When to test Cytotoxic Drug Safety Cabinets?
• On site immediately prior to initial use.
• After relocation.
• After mechanical or electrical maintenance (including HEPA filter replacement).
• At least on a 12 monthly basis.

COMPLIANCE TEST REQUIREMENTS

Typical tests performed to certify a CDSC, as per AS 2252.5 (2017):

• Air velocity and uniformity in the work zone.
• Work zone integrity.
• HEPA filter installation integrity.
• Air classification (particle counting) - ISO 5.
• Air barrier containment.
• Noise level.
• Illuminance.
• Alarm operational check (if applicable).
• Intensity of UV radiation (if applicable).